Heart failure & cardiomyopathies
Changes in Cardiac Function Following Fulminant Myocarditis
Authors' conclusion
Some patients with fulminant myocarditis had left ventricular dysfunction in the chronic phase. Patients with reduced left ventricular function at discharge had a worse prognosis than those with preserved left ventricular function.
Study context
- Population
- Patients with biopsy-proven fulminant myocarditis, nationwide registry in Japan153 with left ventricular ejection fraction (LVEF) at 1 year
- Participants
- 214 patients
- Exposure
- LVEF <50% vs LVEF ≥50% at discharge
- Outcome
- Changes in LVEF (on admission, at discharge, 1 year after discharge)
- Follow-up
- 1 year after discharge
Methodological detailsnationwide registry
- Nationwide registry
Main finding
As reported in the abstract
LVEF
- Median (first-third quartiles) LVEF on admission
- 33% (21-45%)
- Median (first-third quartiles) LVEF at discharge
- 59% (49-64%)
- Median (first-third quartiles) LVEF at 1 year
- 61% (55-66%)
- LVEF <50% at discharge
- 45 (29%)
- LVEF <50% at 1 year
- 22 (14%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Death or heart transplantationAdjusted | 8.19 (2.13–31.5) | P = 0.002 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Changes in Cardiac Function Following Fulminant Myocarditis. Circ Heart Fail. Published 4 April 2024. doi:10.
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