Heart failure & cardiomyopathiesCohort study
Fulminant myocarditis proven by early biopsy and outcomes
- Cohort study
- multicentre (36 tertiary centres, 15 countries)
- propensity score-weighted analysis
Study context
- Population
- Adults with clinically suspected fulminant myocarditis admitted to ICUs
- Participants
- 419 adults
- Exposure
- Early endomyocardial biopsy (EMB) vs delayed EMB
- Early EMBn = 103
- Delayed EMBn = 80reference
- Outcome
- Survival free of heart transplantation (HTx) or LV assist device (LVAD)
- Follow-up
- 1 year
Main finding
As reported in the abstract
Odds ratio
0.44
95% CI 0.22–0.86
P = 0.016
By group
Early EMB vs Delayed EMB
OR 0.44 (95% CI 0.22–0.86); P = 0.016
Observational data: associations, not effects.
Further findings
Survival free of HTx/LVAD, propensity score-weighted · 1 year · propensity score weighting
P = 0.021
Survival without HTx/left ventricular assist device (LVAD), whole cohort
- Survived without HTx/LVAD
- 273 (65%)
Original publication
Fulminant myocarditis proven by early biopsy and outcomes. Eur Heart J. Published 6 November 2023. doi:10.1093/eurheartj/ehad707
Summarised from the published abstract; every number is checked against it