Changes in frailty and incident cardiovascular disease in three prospective cohorts
An erratum to this article was published (Eur Heart J, 21 May 2024 ↗)
Authors' conclusion
Different changes in frailty status are associated with different risks of incident CVD. Progression of frailty status increases incident CVD risks, while recovery of frailty status decreases incident CVD risks.
Study context
- Population
- Adults in three prospective cohorts (China Health and Retirement Longitudinal Study (CHARLS), English Longitudinal Study of Ageing (ELSA), Health and Retirement Study (HRS)); frailty by Rockwood frailty index at baseline and 2 years laterCHARLS 7116, ELSA 5303, HRS 7266
- Exposure
- Changes in frailty status vs stable frailty status
- Outcome
- Incident cardiovascular disease (CVD) (self-reported physician-diagnosed heart disease or stroke)
- Follow-up
- Median 5.0 years (CHARLS), 10.7 years (ELSA), 9.5 years (HRS)
Methodological detailsthree cohorts (CHARLS, ELSA, HRS)
- Three cohorts (CHARLS, ELSA, HRS)
Main finding
As reported in the abstract
Incident CVD
Hazard ratio (95% CI)
Robust → pre-frail/frailvs Stable robustCHARLS
1.84(1.54–2.21)
Robust → pre-frail/frailvs Stable robustELSA
1.53(1.25–1.86)
Robust → pre-frail/frailvs Stable robustHRS
1.59(1.31–1.92)
Frail → robust/pre-frailvs Stable frailCHARLS
0.62(0.47–0.81)
Frail → robust/pre-frailvs Stable frailELSA
0.49(0.34–0.69)
Frail → robust/pre-frailvs Stable frailHRS
0.70(0.55–0.89)
Pre-frail → robustvs Stable pre-frailCHARLS
0.66(0.52–0.83)
Pre-frail → robustvs Stable pre-frailELSA
0.65(0.49–0.85)
Pre-frail → robustvs Stable pre-frailHRS
0.71(0.56–0.91)
Observational data: associations, not effects.
Original publication
Changes in frailty and incident cardiovascular disease in three prospective cohorts. Eur Heart J. Published 18 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →