Heart failure & cardiomyopathies
Characteristics and Prognosis of Wild-Type Transthyretin Amyloid Cardiomyopathy Patients Diagnosed Before 65 Years Old
Authors' conclusion
ATTRwt-CM diagnosed before 65 years shows a distinct phenotype
Study context
- Population
- Patients with wild-type ATTR-CM and documented symptom onset in the HEAR registry, July 2021 to May 20243,980 ATTR enrolled
- Participants
- 1,417 patients
- Exposure
- ATTRwt-CM diagnosed ≤65 years vs >65 years
- ATTRwt-Yyn = 67
- ATTRwt-Oyn = 111
- ATTRwt-Oon = 1,239reference
- Outcome
- Proportion by age at diagnosis and symptom onset
Methodological detailsmulticenter, noninterventional, longitudinal registry
- Multicenter
- Noninterventional
- Longitudinal registry
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Diagnostic delay
HF signs at presentation
- Diagnostic delay: P < 0.001
- HF signs at presentation: P < 0.001
Extracardiac manifestations and rhythm disturbances
- ATTRwt-Yy had more extracardiac manifestations, notably osteoarticular disease; rhythm disturbances predominated in ATTRwt-Oy
Median follow-up from diagnosis
- Median follow-up from diagnosis: 36.2 (ATTRwt-Yy), 23.6 (ATTRwt-Oy) and 22.4 (ATTRwt-Oo) months
Survival after diagnosis
- Better survival after diagnosis in ATTRwt-Yy vs ATTRwt-O
Original publication
Characteristics and Prognosis of Wild-Type Transthyretin Amyloid Cardiomyopathy Patients Diagnosed Before 65 Years Old. JACC Adv. Published 21 November 2025. doi:10.
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