Heart failure & cardiomyopathies
Incidence and risk factors for malignancy after heart transplantation- Analysis of the UNOS Registry
Authors' conclusion
De novo malignancy is common, occurring in one-fifth of recipients after heart transplant. Risk factors for de novo malignancy included older age, male gender, induction immunosuppression, and history of cigarette use. Hospitalization for infection is a risk factor that has not been previously described.
Study context
- Population
- Heart transplant recipients, United Network for Organ Sharing registry
- Participants
- 50,370 recipients
- Outcome
- Incidence of de novo post-transplant malignancy
- Follow-up
- 10 years
Methodological detailsregistry analysis (UNOS)
- Registry analysis (UNOS)
Main finding
As reported in the abstract
De novo post-transplant malignancy
Incidence of de novo post-transplant malignancy
20.6%
Observational data: associations, not effects.
Further findings
Risk factors for de novo malignancy
| OR (95% CI) | ||
|---|---|---|
| Older age | 1.05 (1.049–1.060) | |
| Induction with OKT3 | 1.47 (1.23–1.76) | |
| >1 induction agent | 1.44 (1.14–1.82) | |
| History of cigarette use | 1.19 (1.11–1.28) | |
| Hospitalization for infection | 1.26 (1.18–1.34) | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Risk factors for de novo malignancyFemalevs Male | 0.63 (0.58–0.68) | |
| 0.512Odds ratio (log scale) |
Incidence by malignancy type · 10 years
- Nonmelanoma skin cancer
- 9.0%
- Solid-organ cancer
- 6.2%
- Lymphoproliferative disorder
- 1.2%
Original publication
Incidence and risk factors for malignancy after heart transplantation- Analysis of the UNOS Registry. Am Heart J. Published 21 November 2025. doi:10.
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