Heart failure & cardiomyopathies
Characterization of ventricular tachycardia ablation in end-stage heart failure patients with left ventricular assist device (CHANNELED registry)
Authors' conclusion
Although often a last resort, VT ablation in patients with LVAD is feasible and safe when performed in experienced centres. These patients suffer from a high scar burden, and cardiomyopathy-associated rather than cannula-related scar seems to be the dominant substrate. Ventricular tachycardia recurrence is high despite extensive treatment, and the overall prognosis is limited.
Study context
- Population
- Patients with LVAD referred for ventricular tachycardia (VT) ablation
- Participants
- 69 patients72 ablation procedures
- Outcome
- VT mechanism, acute procedural result, VT recurrence and mortality after VT ablation
- Follow-up
- Median 283 days (IQR 70-587 days)
Methodological details9 tertiary care centres
- 9 tertiary care centres
Main finding
As reported in the abstract
- Scar-related re-entry VT
- 76/96 VTs; 79%
- LVAD cannula-related VT
- 19/96 VTs (20%)
- Non-inducibility of any VT
- 28/72 procedures (39%)
- Transplanted
- 10/69 (14%)
- Died
- 26/69 (38%)
- Free from VT
- 16/69 (23%)
- Lost to follow-up
- 3/69
Observational data: associations, not effects.
Safety
- No LVAD-related complication observed
Original publication
Characterization of ventricular tachycardia ablation in end-stage heart failure patients with left ventricular assist device (CHANNELED registry). Europace. Published 18 March 2025. doi:10.
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