Heart failure & cardiomyopathies
Platelet Count in Heart Failure Patients Undergoing Left Ventricular Assist Device
Authors' conclusion
LVAD implantation could improve the PLT count towards normalization. Abnormal pre-/post-implant PLT counts were independently associated with increased risks of long-term mortality.
Study context
- Population
- Patients receiving a first continuous-flow left ventricular assist device (LVAD) for end-stage HF, Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) registry
- Participants
- 19,517 patients
- Exposure
- High or low vs intermediate platelet (PLT) count
- Outcome
- Long-term mortality
Methodological detailsregistry-based (INTERMACS)
- Registry-based (INTERMACS)
Main finding
As reported in the abstract
Mortality by pre-implant PLT count · 2 years
Each group vs intermediateHazard ratio (95% CI)P value
High
1.09(1.01–1.17)
P = 0.033Low
1.18(1.10–1.27)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality by post-implant PLT count · 4 yearsHighvs IntermediatePost-implant PLT count | 1.38 (1.26–1.52) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
PLT count after LVAD implantation
- Dynamic change towards normalization after LVAD implantation
- U-shaped association of pre- and post-implant PLT counts with mortality risk
Original publication
Platelet Count in Heart Failure Patients Undergoing Left Ventricular Assist Device. ESC Heart Fail. Published 3 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →