Aortic & peripheral vascular disease
Characterization of peripheral artery disease and associations with traditional risk factors, mobility, and biomarkers in the project baseline health study
Authors' conclusion
This study reinforces existing evidence that a large proportion of PAD without claudication may be underdiagnosed, particularly in female and Black or African American participants.
Study context
- Population
- Participants of the Project Baseline Health Study (PBHS), recruited 2017–2018
- Participants
- 2,209 participants
- Exposure
- Peripheral artery disease (PAD) vs normal ABI
- PADn = 58
- Outcome
- Prevalence of lower-extremity PAD
- Follow-up
- Baseline
Methodological detailsmulticentre, longitudinal
- Multicentre
- Longitudinal
Main finding
As reported in the abstract
| Group | Value | Pre-existing PAD diagnosed prior to enrollment |
|---|---|---|
| PAD | 2.6% | 2 (3.4%) |
PAD
Value2.6%
Pre-existing PAD diagnosed prior to enrollment2 (3.4%)
Observational data: associations, not effects.
Further findings
Risk factors, coronary calcification and hs-CRP · baseline
Smoking
P < 0.001
Hypertension
P < 0.001
DM
P = 0.031
Agatston score >100
P = 0.01
hs-CRP PAD 5.86 · Normal ABI 2.83 · P < 0.001
Immunophenotype (adjusted for demographic and risk factors) · baseline
- Significantly fewer circulating CD56-high NK cells, IgM+ memory B cells and CD10/CD27 double-positive B cells with PAD
- P < 0.05 for all
Original publication
Characterization of peripheral artery disease and associations with traditional risk factors, mobility, and biomarkers in the project baseline health study. Am Heart J. Published 3 July 2024. doi:10.
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