Heart failure & cardiomyopathiesCohort study
Characterizing clinically recognized hypertrophic cardiomyopathy in six European countries using real-world data
- retrospective cohort study
- routinely collected healthcare data from six European countries
- mapped to the Observational Medical Outcomes Partnership (OMOP) Common Data Model within the DARWIN EU® network
Authors' conclusion
An increase in the prevalence of clinically recognized HCM across Europe was observed over time. This trend is likely multifactorial and may reflect changes in disease recognition, clinical practice, demographics, database-related factors, and potentially the underlying disease burden. Cardiovascular comorbidities and treatments were frequently recorded prior to diagnosis, which may suggest that some patients would benefit from increased diagnostic awareness.
Study context
- Population
- Adults (≥18 years) with a first recorded hypertrophic cardiomyopathy (HCM) or obstructive HCM (oHCM) diagnosis after 2010 in six European countriesindividuals with HCM, 12,363 (31%) first diagnosed with oHCM
- Participants
- 40,277 adults
- Exposure
- HCM vs oHCM
- HCMn = 40,277
- oHCMn = 12,363
Main finding
As reported in the abstract
Females
67-78
median · years
Males
57-68
median · years
Observational data: associations, not effects.
Further findings
Annual period prevalence
- Increased over time; lowest
- 0.04% (95% Confidence interval: 0.04-0.05)
- Highest, in recent years
- 0.24% (0.23-0.24)
- Prevalence was higher in males, but differences diminished among those aged ≥80 and with oHCM
Recorded comorbidities and treatments · before and at the time of first diagnosis
- Cardiovascular comorbidities frequently recorded, especially hypertension, cardiac arrhythmias, ischaemic heart disease, and heart failure
- Beta-blockers, diuretics, and angiotensin-converting enzyme inhibitors were the most common treatments
- Most comorbidities and treatments were recorded over a year before HCM diagnosis
Original publication
Summarised from the published abstract; every number is checked against it