Heart failure & cardiomyopathies
Treatment Patterns, Outcomes and Healthcare Resource Utilization of Obstructive Hypertrophic Cardiomyopathy in England
Authors' conclusion
Obstructive HCM is associated with a large clinical and economic burden in England, and this burden increases with higher NYHA class. These findings support the need for new and more effective strategies for the management of HCM.
Study context
- Population
- Adults (≥18 years at index date) diagnosed with obstructive hypertrophic cardiomyopathy (HCM) in routine clinical practice in England, Clinical Practice Research Datalink (CPRD) GOLD/Aurum and linked Hospital Episode Statistics (HES) databases (1 April 2007 to 30 October 2020)patients in the overall HCM cohort
- Participants
- 6,440 adults
- Exposure
- Outcomes stratified by New York Heart Association (NYHA) class at baseline and during follow-up
- Outcome
- Follow-up duration
Main finding
As reported in the abstract
Mean follow-up duration (SD)
4.84 [standard deviation (SD): 2.95] years
Observational data: associations, not effects.
Further findings
Pre-specified prior medical condition · baseline
| Outcome | NYHA class I | NYHA class II+ |
|---|---|---|
| Total HCRU costs per patient-year | £3033 | £4517 |
Baseline characteristics
- Male
- 61.9%
- White
- 79.1%
- Mean (SD) age
- 61.02 (15.61) years
Pre-specified prior medical condition · baseline
- Proportion with at least one baseline active prescription for cardiovascular-related medication increased with higher NYHA class
Treatment change during follow-up · follow-up period
- Among patients with at least one record of a prescription for the treatment of symptomatic obstructive HCM, experienced a treatment change
- 41.7%
Clinical events
- Atrial fibrillation or flutter, ischaemic stroke and heart failure were the most observed clinical events; first in-study incidence increased with higher NYHA class
Total healthcare resource utilization (HCRU) costs per patient-year
- Secondary care costs consistently the main driver
Original publication
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