Chest pain patterns and coronary microvascular function in non-obstructive coronary artery disease
Authors' conclusion
ANOCA patients with exertional CP demonstrated worse microvascular function than those with resting CP, with endothelium-independent CMD showing a significant prognostic impact. Exertional CP patients may benefit more from treatment strategies specifically targeting CMD.
Study context
- Population
- Patients with angina and non-obstructive coronary arteries (ANOCA) who underwent coronary reactivity testing
- Participants
- 1,264 patients
- Comparison
- Microvascular function and prognosis were compared between patients with exertional CP and resting CP.
- Outcome
- CP pattern distribution
Main finding
As reported in the abstract
- Median age
- 52 years
- Women
- 65.3%
Further findings
| Outcome | Exertional CP | Resting CP | Both | P value | |
|---|---|---|---|---|---|
| CFRExertional CP vs Resting CP · lower in exertional CP | 2.8 | 3.0 | Not reported in the abstract | P = 0.014 | Both: not reported in the abstract |
| Endothelium-independent CMD prevalenceExertional CP vs Resting CP · higher in exertional CP | 32.1% | 24.4% | Not reported in the abstract | P = 0.034 | Both: not reported in the abstract |
| CBF increase in response to acetylcholineExertional CP vs Resting CP · lower in exertional CP | 38.2% | 50.7% | Not reported in the abstract | P = 0.015 | Both: not reported in the abstract |
Prognostic impact of endothelium-independent coronary microvascular dysfunction (CMD) (survival analysis) · median 7-year follow-up
- Endothelium-independent CMD significantly increased risk in exertional CP patients
- P = 0.002
- Not in resting CP patients
- P = 0.388
Original publication
Chest pain patterns and coronary microvascular function in non-obstructive coronary artery disease. EuroIntervention. Published 1 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it