Acute cardiac care & resuscitation
Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial
Primary result · Hemostatic efficacy scoreResult — go to the resultMean difference 0.09 95% CrI −0.06 to 0.23Authors' conclusion
For patients undergoing cardiac surgery, CSPs stored up to 21 days are noninferior to RTPs for the control of active surgical bleeding.
Study context
- Population
- Pediatric and adult patients undergoing cardiac surgery with planned cardiopulmonary bypass, actively bleeding989 in primary analysis
- Participants
- 1,000 participants
- Comparison
- Cold-stored platelets vs room-temperature platelets
- Cold-stored platelets (CSPs)n = 650
- Room-temperature platelets (RTPs)n = 339reference
- Primary endpoint
- Hemostatic efficacy score (1 to 5; higher = greater bleeding); non-inferiority margin 1 point
Methodological detailsphase 3, multicentre, partially blinded, adaptive, non-inferiority, storage duration-ranging, 27 sites in the US and Australia
- Phase 3
- Multicentre
- Partially blinded
- Adaptive
- Non-inferiority
- Storage duration-ranging
- 27 sites in the US and Australia
Primary result
Hemostatic efficacy score
Mean difference
0.09
95% CrI −0.06 to 0.23
CSPs vs RTPs
mean difference 0.09 (95% CrI −0.06 to 0.23)
Non-inferiority margin 1 as printed, not drawn
As reported in the abstract
- CSPs non-inferior to RTPs for all cold-storage durations; probability
- >99.9%
Secondary outcomes
Median, mL/kg
| Outcome | CSPs | RTPs | Difference in medians (95% CI) | |
|---|---|---|---|---|
| Chest tube output · 24 hours · not statistically different | 8.9 (IQR 5.2–15.4) | 8.4 (IQR 5.5–15.9) | 0.4 (−1.0 to 1.5) | |
| −2−1012Difference (linear scale) |
Mean
| Outcome | CSPs | RTPs | Estimate |
|---|---|---|---|
| Hemostatic efficacy score, CSPs as single group (post hoc) · post hoc analysis | 3.08 (SD 1.15) | 2.99 (SD 1.10) |
Safety
Thrombotic events, transfusion-associated AEs, ARDS, kidney failure, septic shock, mortality, reexploration
- No differences in venous or arterial thrombotic events, transfusion-associated adverse events, ARDS, kidney failure, septic shock or mortality
- Increased reexploration rates with CSPs
Original publication
Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial. JAMA. Published 17 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it