Heart failure & cardiomyopathies
Choline Metabolites, Genetic Susceptibility, and Incident Heart Failure
Authors' conclusion
Circulating choline metabolites were associated with the risk of incident HF, independent of genetic susceptibility.
Study context
- Population
- UK Biobank participants free of CVD at baseline (2006–2010)5,468 incident heart failure (HF) cases
- Participants
- 245,072 participants
- Exposure
- Circulating choline metabolites and incident HF
- Outcome
- Incident HF
- Follow-up
- Median 14.1 years
Methodological detailstwo-sample Mendelian randomization
- Two-sample Mendelian randomization
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Total choline, per one SD increase
1.08(1.04–1.12)
Phosphatidylcholine, per one SD increase
1.08(1.05–1.12)
Total choline, highest quartilevs lowest quartile
1.23(1.12–1.35)
Phosphatidylcholine, highest quartilevs lowest quartile
1.23(1.12–1.34)
Glycine, per one SD increase
0.97(0.94–0.99)
Observational data: associations, not effects.
Further findings
HF, Mendelian randomization
| OR (95% CI) | ||
|---|---|---|
| Total choline | 1.71 (1.01–1.35) | |
| Glycine | 0.93 (0.88–0.99) | |
| 0.512Odds ratio (log scale) |
Joint association with polygenic risk score
- High polygenic risk score and high total choline or phosphatidylcholine had the highest HF risk; low polygenic risk score and high glycine the lowest
- No statistically significant interactions between choline metabolites and genetic susceptibility to HF
Original publication
Choline Metabolites, Genetic Susceptibility, and Incident Heart Failure. JACC Adv. Published 14 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →