Heart failure & cardiomyopathies
Small Heart Size and Premature Death in 366,484 Individuals With Normal Ejection Fraction
Authors' conclusion
In individuals with normal LVEF, small ventricular size is associated with increased mortality, particularly among females and those with higher LVEF.
Study context
- Population
- Adults with left ventricular ejection fraction (LVEF) ≥50% undergoing transthoracic echocardiography, multicentre cohort (subset 279,442 with LVEF ≥60%)65,241 deaths
- Participants
- 366,484 adults
- Exposure
- Smallest vs larger LV chamber size quartiles
- Outcome
- All-cause mortality (National Death Index linkage)
- Follow-up
- 5 years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
5-year all-cause mortality
Smallest LVEDVi quartile vs larger: higher odds of 5-year all-cause mortality, greater with high-normal LVEF
14% to 18%
Observational data: associations, not effects.
Further findings
CV mortality, females, smallest LVEDVi quartile
- Increased odds of CV mortality
- 17%
- Increased odds of CV mortality, LVEF ≥60%
- 30%
CV mortality, men
- No significant association between smallest cardiac size and CV mortality
Original publication
Small Heart Size and Premature Death in 366,484 Individuals With Normal Ejection Fraction. JACC Adv. Published 13 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →