Arrhythmias & electrophysiology
Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis
Authors' conclusion
Increased BMP10 levels were associated with persistent AF history, increased late POAF incidence, and LAA endomysial fibrosis in a diverse sample of patients undergoing cardiac surgery.
Study context
- Population
- Patients with and without preoperative atrial fibrillation (AF) history undergoing first cardiac surgery (RACE V)
- Participants
- 147 patients
- Outcome
- Associations of circulating BMP10 with persistent AF history, late postoperative atrial fibrillation (POAF) and LA fibrosis
Main finding
As reported in the abstract
BMP10Estimate (95% CI)P value
History of persistent AF; adjusted multinomial logistic regression
OR 1.24(1.10–1.40)
P = 0.001Late POAF90; adjusted for age, sex, AF history, early POAF
HR 1.07 per 0.1 ng/mL increase(1.00–1.14)
P = 0.041Per 0.1 ng/mL increase, as printed
- LA endomysial fibrosis vs BMP10, standardized β
- 0.22, P = 0.041
- LA overall fibrosis vs BMP10 (not correlated), standardized Β
- 0.12, P = 0.261
Observational data: associations, not effects.
Original publication
Circulating BMP10 Levels Associate With Late Postoperative Atrial Fibrillation and Left Atrial Endomysial Fibrosis. JACC Clin Electrophysiol. Published 1 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it