Clinical and economic outcomes following first-time myocardial infarction: a nationwide cohort study from the SWEDEHEART registry
Authors' conclusion
First-time MI patients have persistently higher risks of cardiovascular death, MI, and ischaemic stroke, along with greater healthcare use and costs, underscoring the need for effective prevention.
Study context
- Population
- First-time myocardial infarction (MI) patients from the nationwide SWEDEHEART registry and matched controls without prior MI, 2012–2022
- Participants
- 118,810 vs 588,687
- Exposure
- Comparing outcomes, healthcare resource use, and associated costs between first-time MI patients and matched controls
- First-time MI patientsn = 118,810
- Matched controlsn = 588,687reference
- Outcome
- Major adverse cardiovascular events (MACE):
- Cardiovascular death
- MI
- Ischaemic stroke
- Acute limb ischaemia
- Urgent arterial revascularization
- Follow-up
- 10-year
Methodological detailsmatched controls (matched by sex, age, and region)
- Matched controls (matched by sex, age, and region)
Main finding
As reported in the abstract
first-time MI patients vs matched controlsEstimate (95% CI)
MACE (cardiovascular death, MI, ischaemic stroke, acute limb ischaemia, or urgent arterial revascularization)
HR 3.65(3.61–3.69)
After adjustment for baseline characteristics
adjHR 3.18(3.15–3.22)
Observational data: associations, not effects.
Further findings
Cardiovascular death, MI, arterial revascularization · 10-year
Cardiovascular death
MI
Arterial revascularization
| Outcome | First-time MI patients | Matched controls |
|---|---|---|
| Healthcare resource use and costs | ||
| Inpatient visits | 0.65/patient year | 0.32/patient year |
| Inpatient days | 3.05/patient year | 1.67/patient year |
| Mean annual total costs | €7266 | €3934 |
Healthcare resource use and costs
- Differences were greatest in the first year but persisted, especially among females and those with risk factors such as hypertension or diabetes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical and economic outcomes following first-time myocardial infarction: a nationwide cohort study from the SWEDEHEART registry. Eur Heart J Qual Care Clin Outcomes. Published 25 April 2026. doi:10.
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