Valvular & structural heart disease
Clinical Characteristics and Outcomes of Patients Screened for Transcatheter Tricuspid Valve Replacement: The TriACT Registry
Authors' conclusion
This first real-world report of TTVR screening demonstrated a high screening failure rate, mainly related to large tricuspid annular diameter. Patients undergoing TTVR had superior TR reduction and symptom alleviation compared with bailout tricuspid transcatheter edge-to-edge repair, at the cost of greater procedural complications.
Study context
- Population
- Patients with tricuspid regurgitation (TR) screened for transcatheter tricuspid valve replacement (TTVR) at 7 centres on a compassionate-use basisscreened
- Participants
- 149 patients
- Exposure
- TTVR vs bailout tricuspid TEER after failed TTVR screening
- Outcome
- NYHA functional class and TR grade
- Follow-up
- 30-day follow-up
Methodological details7 centres, compassionate use
- 7 centres
- Compassionate use
Main finding
As reported in the abstract
NYHA class I or II (baseline to 30 days) and TR ≤1+ at 30 days
| Group | NYHA I or II | TR ≤1+ |
|---|---|---|
| TTVR | from 21% to 68%; P < 0.001 | 97% (P < 0.001 from baseline) |
| Bailout TEER | from 27% to 58%; P < 0.001 | 43% (P < 0.001 from baseline) |
NYHA I or II
TTVRfrom 21% to 68%; P < 0.001
Bailout TEERfrom 27% to 58%; P < 0.001
TR ≤1+
TTVR97% (P < 0.001 from baseline)
Bailout TEER43% (P < 0.001 from baseline)
Observational data: associations, not effects.
Secondary outcomes
TTVR screening failure rate
- Screening failure rate, mainly large tricuspid annular diameter
- 74%
Technical success
- Technical success
- 91%
All-cause mortality · 30 days
- Mortality
- 8%
HF hospitalization · 30 days
- HF hospitalization
- 5%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical Characteristics and Outcomes of Patients Screened for Transcatheter Tricuspid Valve Replacement: The TriACT Registry. JACC Cardiovasc Interv. Published 26 February 2024. doi:10.
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