Valvular & structural heart diseaseCohort study
Management and Outcome of Failed Transcatheter Tricuspid Edge-to-Edge Repair
- Retrospective cohort study
- multicentre
- registry (FATE)
- 31 centres
Authors' conclusion
Device-related failure after T-TEER is uncommon but clinically relevant. Reintervention achieves greater TR reduction and right atrial reverse remodeling than medical therapy, but events remain similar between both strategies.
Study context
- Population
- Consecutive tricuspid transcatheter edge-to-edge repair (T-TEER) procedures with device-related failure (loss of leaflet insertion, single-leaflet device attachment or embolization) with moderate or greater residual or recurrent tricuspid regurgitation (TR), 2017–2024
- Participants
- 2,278 T-TEER procedures
- Exposure
- Reintervention vs medical therapy for T-TEER device-related failure
- Outcome
- Coprimary: incidence and management of device-related failure; composite of death or HF rehospitalization
Main finding
As reported in the abstract
- Device-related failure incidence (123 failures)
- 5.4%
- Loss of leaflet insertion
- 24%
- Single-leaflet device attachment
- 75%
- Embolization
- 1%
- Severe or greater TR with failure
- 73%
- Management: medical therapy
- 54%
- Management: reintervention
- 46%
- Death or HF rehospitalization (median follow-up 255 days); did not differ between strategies
- 38.2%
Observational data: associations, not effects.
Further findings
TR reduction and right atrial reverse remodeling
- Greater with reintervention than medical therapy
Predictors of adverse outcomes
- Higher TRI-SCORE, AKI and greater discharge TR severity independently predicted adverse outcomes
Original publication
Management and Outcome of Failed Transcatheter Tricuspid Edge-to-Edge Repair. JACC Cardiovasc Interv. Published 23 March 2026. doi:10.1016/j.jcin.2026.01.285
Summarised from the published abstract; every number is checked against it