Clinical Characteristics Associated With Variability in Biopsy Grade Severity of Liver Fibrosis in Fontan Circulation
Authors' conclusion
Liver fibrosis in FC progresses with duration of exposure, independent of venous pressure, suggesting ongoing fibrogenesis even at acceptable hemodynamics. Younger age at FO is associated with greater fibrosis severity
Study context
- Population
- Patients with Fontan circulation undergoing standardized evaluation incl. cardiac catheterization, percutaneous liver biopsy, liver elastography and blood laboratories
- Participants
- 173 patients
- Outcome
- Liver fibrosis severity by Sirius red % staining of liver biopsy specimens, and its associations with clinical and hemodynamic factors
Main finding
As reported in the abstract
Liver fibrosis severity (Sirius red % staining on liver biopsy)
- Sirius red % staining correlated with aspartate aminotransferase/platelet ratio
- P = 0.026
Observational data: associations, not effects.
Further findings
Patient and hemodynamic characteristics
- Median age at Fontan operation (FO), years (range: 0.5-15)
- 2.2
- Median age at biopsy, years (range: 4.7-39.4)
- 17.5
- Dominant RV morphology
- 67%
Years of Fontan circulation (FC) exposure vs other measures
- Years of FC exposure correlated positively with hemoglobin, gamma glutamyl transferase and liver elastography
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical Characteristics Associated With Variability in Biopsy Grade Severity of Liver Fibrosis in Fontan Circulation. JACC Adv. Published 15 December 2025. doi:10.
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