Clinical Characteristics, Diagnosis and Short-Term Outcomes of COVID-19–Associated Acute Myocarditis in China
Authors' conclusion
The majority of COVID-19-associated AM occurred within 2 weeks of Omicron variant infection. Fulminant myocarditis complicated by hemodynamic instability requiring temporary mechanical circulatory support was not uncommon. However, short-term outcome was generally good and most AM patients fully recovered.
Study context
- Population
- Patients with definite COVID-19 (Omicron)-associated acute myocarditis, 6 hospitals in China, 1 December 2022–30 June 2023
- Participants
- 28 patients6 hospitals
- Outcome
- Clinical characteristics, disease course and short-term outcomes
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Age, median (Q1-Q3: 22-52) years
- 37
- Men
- 53.6%
- Acute myocarditis (AM) onset within 2 weeks of COVID-19 onset
- 23
- Endomyocardial biopsy
- 10
- Fulminant myocarditis requiring inotropes or temporary mechanical circulatory support
- 7 (25.0%)
- Left ventricular ejection fraction (LVEF) <50% on admission
- 9 (32.1%)
- Of these, fully recovered LVEF at discharge
- 5
- Of these, improved LVEF but below normal at discharge
- 2
- Corticosteroids prescribed
- 18 (64.3%)
- Temporary mechanical circulatory support
- 7 (25.0%)
- In-hospital deaths
- 2
Observational data: associations, not effects.
Further findings
Cardiac magnetic resonance (CMR) ECV, first follow-up vs baseline
- ECV decreased: 28.95 (25.38, 32.55)% vs 33.65 (31.58, 37.55)%
- P = 0.028
- Other CMR parameters: no significant changes
Original publication
Clinical Characteristics, Diagnosis and Short-Term Outcomes of COVID-19–Associated Acute Myocarditis in China. ESC Heart Fail. Published 19 September 2024. doi:10.
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