Clinical characteristics, management and outcomes of enterococcal infective endocarditis: an ancillary study from the ESC-EORP EURO-ENDO registry
Authors' conclusion
EIE affects older, high-risk patients. After adjustment for operative risk, mortality was comparable to other aetiologies, highlighting the need for tailored diagnostic and therapeutic strategies.
Study context
- Population
- Adult patients with definite or possible infective endocarditis (IE) enrolled in the ESC-EORP EURO-ENDO registry between January 2016 and March 2018365 (12%) had monomicrobial enterococcal infective endocarditis (EIE)
- Participants
- 3,083 patients
- Exposure
- EIE vs. non-enterococcal IE
- EIEn = 365
- Outcome
- Age
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prosthetic valve involvement
| Outcome | EIE | NEIE | Adjusted OR (95% CI) | P value | |
|---|---|---|---|---|---|
| In-hospital mortalityAdjusted for EuroSCORE II and valve status · multivariable logistic regression | 16% | 17% | 0.67 (0.42–1.04) | P = 0.083 | |
| 0.512Adjusted odds ratio (log scale) |
Prosthetic valve involvement
- Aortic valve localization and colonic uptake on PET/CT more common in EIE
Recurrence among 195 EIE patients with 1-year follow-up
- Recurrence among 195 EIE patients with 1-year follow-up
- 6%
- Healthcare-associated acquisition, prosthetic valve infection, and recurrence associated with worse outcomes and lower surgical rates
Original publication
Clinical characteristics, management and outcomes of enterococcal infective endocarditis: an ancillary study from the ESC-EORP EURO-ENDO registry. Eur Heart J Qual Care Clin Outcomes. Published 27 November 2025. doi:10.
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