Neutrophil-to-Lymphocyte Ratio and Mortality in Cardiovascular Disease or Cancer: A Population-Based Cohort Study
Authors' conclusion
Higher NLR is associated with greater mortality in adults with and without CVD, HF or cancer
Study context
- Population
- People aged >50 years in 2012 with neutrophil-to-lymphocyte ratio (NLR) measured 2014–2015
- Participants
- 223,388 people
- Exposure
- Highest NLR quartile, within 5 exclusive groups
- CV risk factors onlyn = 106,973
- Cardiovascular disease (CVD)n = 14,490
- Heart failure (HF) or loop diureticsn = 23,009
- Cancern = 8,677
- Nonen = 70,239
- Outcome
- Mortality
- Follow-up
- Tracked until December 2019; median 5.0 years (IQR: 4.4-5.0)
Methodological detailsNHS records, Greater Glasgow & Clyde
- NHS records, Greater Glasgow & Clyde
Main finding
As reported in the abstract
Mortality, highest NLR quartile
Hazard ratio (95% CI)
CV risk factors only
2.07(1.98–2.17)
None
2.18(2.02–2.36)
CVD
1.87(1.70–2.04)
HF or loop diuretics
2.10(1.98–2.24)
Cancer
2.30(2.10–2.52)
Observational data: associations, not effects.
Further findings
Median
| Outcome | None | HF or loop diuretics | Cancer |
|---|---|---|---|
| NLRLowest in None; highest in HF or loop diuretics and Cancer | 2.0 (interval 1.5–2.7) | 2.7 (interval 1.9–3.9) | 2.7 (interval 1.9–4.1) |
Original publication
Neutrophil-to-Lymphocyte Ratio and Mortality in Cardiovascular Disease or Cancer: A Population-Based Cohort Study. JACC Adv. Published 26 November 2025. doi:10.
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