Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group
Authors' conclusion
This first international study provides novel evidence that MVA is an important health problem regardless of sex or ethnicity that a diagnosis of MVA portends a substantial risk for MACE associated with hypertension and previous history of CAD, and that women have a lower quality of life than men despite the comparable prognosis.
Study context
- Population
- Patients with microvascular angina (COVADIS criteria), 14 institutes in 7 countries, 2015–201864% female
- Participants
- 686 patients
- Exposure
- Men vs women
- Outcome
- MACE:
- CV death
- Non-fatal MI
- Non-fatal stroke
- Hospitalization for HF
- Unstable angina
- Follow-up
- Median 398 days (IQR 365-744)
Methodological detailsinternational, multicentre
- International
- Multicentre
Main finding
As reported in the abstract
MACE · median 398 days
P = 0.19
- Total major cardiovascular events (MACE) events
- 78
Observational data: associations, not effects.
Further findings
Prognosis by ethnicity
- No sex or ethnic difference in prognosis
Seattle Angina Questionnaire scores
- Women had lower scores than men
- P < 0.05
Original publication
Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group. Eur Heart J. Published 26 May 2021. doi:10.
Summarised from the published abstract; every number is checked against it