Arrhythmias & electrophysiology
Clinical complexity in patients with atrial fibrillation: exploring differential risk profiles from European and Asian cohorts
Primary result · Composite of all-cause death and MACEResult — go to the resultHazard ratio 1.55 95% CI 1.35–1.77Authors' conclusion
Among AF patients with CC, those enrolled in Asia exhibited marked differences in clinical profiles, management strategies, and outcomes, suggesting greater vulnerability to CC in the Asian population.
Study context
- Population
- Patients with atrial fibrillation (AF) in European (EORP-AF) and Asian (APHRS-AF) registries2,794 (19.9%) met clinical complexity (CC) criteria
- Participants
- 14,055 patients
- Comparison
- Clinical complexity vs no CC in AF
- CCn = 2,794
- Primary endpoint
- Composite of:
- All-cause death
- Major adverse cardiovascular events (MACE) (CV death, ACS, thromboembolic events)
Primary result
Composite of:
Hazard ratio
1.55
95% CI 1.35–1.77
CCvs No CC
HR 1.55 (95% CI 1.35–1.77)
As reported in the abstract
Secondary outcomes
| Outcome | Estimate | |
|---|---|---|
| All-cause death | HR 1.65 (95% CI 1.42–1.93) | |
| MACE | HR 1.50 (95% CI 1.26–1.80) | |
| CV death | HR 1.81 (95% CI 1.40–2.36) | |
| OAC use and rhythm control in patients with CC, Asian vs EuropeanAsianvs EuropeanOAC use | OR 0.75 (95% CI 0.57–1.01) | |
| OAC use and rhythm control in patients with CC, Asian vs EuropeanAsianvs EuropeanRhythm control | OR 0.53 (95% CI 0.41–0.69) | |
| 0.512Ratio (log scale) |
Composite outcome, by region (subgroup)
- Excess risk of composite outcome in Asians
- HR 2.28 (1.57-3.32) (95% CI)
- Excess risk of composite outcome in Europeans
- HR 1.51 (1.31-1.75) (95% CI)
- P-interaction = 0.036
Safety
| Outcome | HR (95% CI) | |
|---|---|---|
| Major bleeding | 2.02 (1.47–2.77) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Clinical complexity in patients with atrial fibrillation: exploring differential risk profiles from European and Asian cohorts. Europace. Published 19 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →