Clinical Decisions and Outcomes After Switching High-Sensitivity Cardiac Troponin Assays in Suspected ACS: An Interrupted Time-Series Study
Main finding · Hospital admissionResult — go to the resultOdds ratio 2.24 95% CI 1.81–2.77Authors' conclusion
The transition from a high-sensitivity assay measuring cardiac troponin I to one measuring cardiac troponin T was associated with increased identification of myocardial injury, serial troponin measurements, and hospital admissions without evidence of improved cardiovascular outcomes at 1 year.
Study context
- Population
- Consecutive patients with suspected ACS presenting to acute care hospitals, October 2020–October 2022
- Participants
- 25,849 patients
- Exposure
- High-sensitivity cardiac troponin T assay vs cardiac troponin I assay
- Before transitionn = 13,146reference
- After transitionn = 12,703
- Outcome
- Hospital admission
Methodological detailsprospective, multicenter, 3 acute care centers
- Prospective
- Multicenter
- 3 acute care centers
Main finding
As reported in the abstract
Odds ratio
2.24
95% CI 1.81–2.77
P < 0.001
After transition vs Before transition
OR 2.24 (95% CI 1.81–2.77); P < 0.001
Observational data: associations, not effects.
Further findings
Myocardial injury
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Subsequent MI, HF or CV death · 1 yearComparable | 0.83 (0.48–1.41) | P = 0.49 | |
| 0.512Odds ratio (log scale) |
- Myocardial injury: P < .001
Serial troponin testing
- 6-fold increase in serial testing with cardiac troponin T vs cardiac troponin I: OR 6.03 (95% CI 4.85-7.49)
- P < 0.001
Original publication
Clinical Decisions and Outcomes After Switching High-Sensitivity Cardiac Troponin Assays in Suspected ACS: An Interrupted Time-Series Study. JAMA Cardiol. Published 1 February 2026. doi:10.
Summarised from the published abstract; every number is checked against it