Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departments
Authors' conclusion
The use of an hs-cTnI assay in an ED population with suspected ACS was associated with lower mortality at 1 year.
Study context
- Population
- Patients ≥20 years old presenting to emergency departments with suspected acute coronary syndrome (ACS) between March 2011 and November 2015preperiod 87,019 · postperiod 92,662
- Participants
- 179,681 consecutive patients
- Comparison
- Postperiod vs preperiod
- Postperiodn = 92,662
- Preperiodn = 87,019reference
- Outcome
- Diagnosis of new MI
Methodological detailsnine tertiary hospitals in Australia, linked administrative data
- Nine tertiary hospitals in Australia
- Linked administrative data
Main finding
As reported in the abstract
P = 0.08
Further findings
Diagnosis of unstable angina
P < 0.0001
| Outcome | Estimate | |
|---|---|---|
| Mortality · 30 days and 1 year30 days, switching to hs-cTnI | adjusted HR 0.88 (CI 0.82–0.95) | |
| Mortality · 30 days and 1 year1 year, switching to hs-cTnI | aHR 0.90 (CI 0.85–0.94) | |
| 0.512Ratio (log scale) |
New myocardial infarction (MI) and unstable angina in non-switching jurisdictions
- In non-switching jurisdictions, rates of new MI remained stable, while diagnoses of unstable angina increased
Mortality · 30 days and 1 year
- The corresponding aHRs for non-switching jurisdictions were not statistically different
Baseline characteristics
- Age
- 62 (SD 19) years
- Women
- 47%
Original publication
Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departments. Heart. Published 16 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it