Arrhythmias & electrophysiology

Clinical/electrophysiologic characteristics of infranodal Wenckebach in patients with indication for permanent ventricular pacing: A prospective study

Heart RhythmPublished Prospective cohort study

Authors' conclusion

Of patients referred for pacemaker implantation, infranodal Wenckebach was present in 27.5% (11/40) without complete AV block. It was as frequent as AV nodal Wenckebach and associated with characteristic electrophysiologic findings.

Study context

Population
Patients with an indication for permanent ventricular pacing undergoing preimplantation electrophysiologic study22 with atrioventricular (AV) Wenckebach
Participants
163 patients
Exposure
Infranodal vs AV nodal Wenckebach
  • Infranodal Wenckebachn = 12
  • AV nodal Wenckebachn = 10reference
Outcome
Prevalence of AV Wenckebach and its type
Methodological details2-year period; ventricular pacing percentage evaluated at 6-month follow-up
  • 2-year period; ventricular pacing percentage evaluated at 6-month follow-up

Main finding

As reported in the abstract

Any AV Wenckebach
22 (13.4%)
Infranodal Wenckebach among patients without complete AV block
27.5% (11/40)

Observational data: associations, not effects.

Further findings

Clinical/electrophysiologic characteristics, infranodal vs AV nodal · LVEF ≤40%

P = 0.04

Clinical/electrophysiologic characteristics, infranodal vs AV nodal · isolated first-degree AV block

P = 0.02

Clinical/electrophysiologic characteristics, infranodal vs AV nodal · RBBB with left anterior fascicular block

P = 0.003

OutcomeP value
Clinical/electrophysiologic characteristics, infranodal vs AV nodalMedian HV interval: 90 vs 49 msP = 0.005
Clinical/electrophysiologic characteristics, infranodal vs AV nodalPR increment at onset of AV Wenckebach: 20.5 vs 80 msP = 0.002
Clinical/electrophysiologic characteristics, infranodal vs AV nodalOnset of 2:1 AV block at longer cycle lengths: 91.7% vs 20%P = 0.002

Original publication

Clinical/electrophysiologic characteristics of infranodal Wenckebach in patients with indication for permanent ventricular pacing: A prospective study. Heart Rhythm. Published 13 May 2024. doi:10.1016/j.hrthm.2024.05.017

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