Arrhythmias & electrophysiology
The PhysioVP-AF study, a randomized controlled trial to assess the clinical benefit of physiological ventricular pacing vs. managed ventricular pacing for persistent atrial fibrillation prevention in patients with prolonged atrioventricular conduction: design and rationale
Study context
- Population
- Patients with indication for permanent DDD pacing for sinus node disease (SND) or intermittent atrioventricular (AV)-block and prolonged AV conduction (PR interval > 180 ms)planned (approximately)
- Participants
- 400 patients
- Planned comparison
- DDD-CSP vs DDD-VPA pacing
- Primary endpoint
- Persistent-AF occurrence
- Follow-up
- 3 years
Methodological detailsdesign and rationale, prospective, single-blind, 1:1 randomisation, 13 Italian centres, ≈400 patients to be randomised in 24 months
- Design and rationale
- Prospective
- Single-blind
- 1:1 randomisation
- 13 Italian centres
- ≈400 patients to be randomised in 24 months
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The PhysioVP-AF study, a randomized controlled trial to assess the clinical benefit of physiological ventricular pacing vs. managed ventricular pacing for persistent atrial fibrillation prevention in patients with prolonged atrioventricular conduction: design and rationale. Europace. Published 28 March 2023. doi:10.
Summarised from the published abstract; every number is checked against it