Clinical event reductions in high-risk patients after renal denervation projected from the global SYMPLICITY registry
Authors' conclusion
Model-based projections suggest radiofrequency renal denervation for patients with uncontrolled hypertension adds considerable clinical benefit across a spectrum of different cohort characteristics.
Study context
- Population
- Patients with uncontrolled hypertension undergoing renal denervation, incl. high-risk subgroups (T2DM, CKD, resistant hypertension, high basal CV risk)full cohort
- Participants
- 2,651 patients
- Exposure
- Radiofrequency renal denervation vs projected control
- Outcome
- MACE
- Follow-up
- 3 years
Methodological detailsglobal, prospective all-comer registry, meta-regression-based projection, sensitivity and scenario analyses
- Global
- Prospective all-comer registry
- Meta-regression-based projection
- Sensitivity and scenario analyses
Main finding
As reported in the abstract
P < 0.01
Observational data: associations, not effects.
Further findings
Office SBP reduction, full cohort
- Mean baseline office SBP (full cohort, N = 2651)
- 166±25 mmHg
- Office SBP reduction (full cohort)
- −14.8 ± 0.4 mmHg
- Mean BP reductions across high-risk subgroups
- −11.0--21.8 mmHg
Projected RR of death and CV events, high-risk subgroups
- Projected RR, lowest (stroke, resistant hypertension)
- 0.57
- Projected RR, highest (death, diabetes)
- 0.92
- Model-based projection
Original publication
Clinical event reductions in high-risk patients after renal denervation projected from the global SYMPLICITY registry. Eur Heart J Qual Care Clin Outcomes. Published 4 September 2022. doi:10.
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