Clinical features and survival in Takayasu’s arteritis-associated pulmonary hypertension: a nationwide study
Authors' conclusion
Patients with TA-PH were predominantly female and had severely compromised haemodynamics. More than 80% of patients in our cohort survived for at least 3 years.
Study context
- Population
- Patients with Takayasu's arteritis with pulmonary artery involvement and pulmonary hypertension, National Rare Diseases Registry System of China, 2007–201981% female
- Participants
- 140 patients
- Outcome
- Time from TA-PH diagnosis to all-cause death
Methodological detailsregistry-based, multicentre
- Registry-based
- Multicentre
Main finding
As reported in the abstract
All-cause survival
| Group | 1-year survival | 3-year survival | 5-year survival |
|---|---|---|---|
| TA-PH | 94.0% | 83.2% | 77.2% |
TA-PH
1-year survival94.0%
3-year survival83.2%
5-year survival77.2%
Observational data: associations, not effects.
Further findings
Predictors of all-cause death
| Comparison | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Syncope | 5.38 (1.77–16.34) | P = 0.003 | |
| NT-proBNP level | 1.04 (1.03–1.06) | P < 0.001 | |
| Mean right atrial pressure | 1.07 (1.01–1.13) | P = 0.015 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
NT-proBNP and haemodynamics with PAH-approved drugs
- Significant improvements in NT-proBNP and haemodynamic profiles
Original publication
Clinical features and survival in Takayasu’s arteritis-associated pulmonary hypertension: a nationwide study. Eur Heart J. Published 10 September 2021. doi:10.
Summarised from the published abstract; every number is checked against it