Arrhythmias & electrophysiology
Clinical Impact of Early Rhythm Control and Healthy Lifestyles in Patients With Atrial Fibrillation
Authors' conclusion
Each of ERC and HLS might reduce the risk of ischemic stroke in patients with new-onset AF. The presence of both ERC and HLS is associated with an enhanced benefit for stroke prevention in this population.
Study context
- Population
- Patients with new-onset atrial fibrillation (AF), Korean National Health Insurance database, 2009–2016
- Participants
- 208,662 patients
- Exposure
- ERC and/or healthy lifestyle (HLS) vs neither
- Group 1n = 46,972reference
- Group 2n = 110,479
- Group 3n = 15,133
- Group 4n = 36,078
- Outcome
- Ischemic stroke
Methodological detailsnationwide database, propensity score weighting
- Nationwide database
- Propensity score weighting
Main finding
As reported in the abstract
Each group vs group 1Hazard ratio (95% CI)
Group 2
0.769(0.728–0.881)
Group 3
0.774(0.703–0.852)
Group 4lowest risk
0.575(0.536–0.617)
Observational data: associations, not effects.
Further findings
Stroke after propensity score weighting
- Additional ERC alongside HLS: relative risk reduction
- 22%
- Additional HLS alongside ERC: relative risk reduction
- 27%
- Propensity score weighting
Original publication
Clinical Impact of Early Rhythm Control and Healthy Lifestyles in Patients With Atrial Fibrillation. JACC Clin Electrophysiol. Published 24 April 2024. doi:10.
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