Arrhythmias & electrophysiology
Early Rhythm Control and Incident Dementia in Patients With Atrial Fibrillation and Prior Stroke
Authors' conclusion
ERC might be beneficial in the prevention of dementia in patients with AF and prior stroke.
Study context
- Population
- Patients with new-onset atrial fibrillation (AF) and prior stroke, Korean nationwide claims database, 2010–2016
- Participants
- 41,370 patients
- Exposure
- Early rhythm control vs usual care
- Early rhythm control (ERC)n = 10,213
- Usual caren = 31,157reference
- Outcome
- Incident dementia (diagnostic codes)
Methodological detailsnationwide claims database, propensity score weighting
- Nationwide claims database
- Propensity score weighting
Main finding
As reported in the abstract
ERC vs Usual careWeighted hazard ratio (95% CI)P value
All dementia
0.825(0.776–0.876)
P < 0.001Alzheimer's dementia
0.831(0.774–0.893)
P < 0.001Vascular dementia
0.800(0.702–0.913)
P < 0.001Observational data: associations, not effects.
Further findings
Dementia, by age (subgroup)
- Benefit of ERC slightly accentuated in younger age group (<65 years)
Dementia, by prior stroke characteristics (subgroup)
- Benefit of ERC consistent regardless of prior stroke characteristics
Original publication
Early Rhythm Control and Incident Dementia in Patients With Atrial Fibrillation and Prior Stroke. JACC Clin Electrophysiol. Published 8 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →