Clinical Outcomes Associated With Various Microvascular Injury Patterns Identified by Cardiac Magnetic Resonance (CMR) After STEMI
Pooled result · Clinical outcome eventResult — go to the resultHazard ratio 3.88 95% CI 1.93–7.80Authors' conclusion
MVI is associated with future adverse outcomes only in patients with a hemorrhagic phenotype (IMH+). Patients with only MVO (MVO+/IMH-) had a prognosis similar to patients without MVI (MVO-/IMH-).
Study context
- Population
- STEMI patients undergoing percutaneous coronary intervention (PCI) with CMR (LGE for microvascular obstruction (MVO), T2* mapping for intramyocardial hemorrhage (IMH))
- Participants
- 1,109 patients3 prospective studies
- Comparison
- Microvascular injury (MVI) patterns: IMH+ vs MVO+/IMH- vs MVO-/IMH-
- MVO+/IMH-n = 274
- IMH+n = 359
- Outcome
- Clinical outcome event (MACE)
- Follow-up
- Median 12 months (Q1-Q3: 12-35 months)
Methodological detailsCMR 3 days after PCI
- CMR 3 days after PCI
Pooled result
Clinical outcome event · median 12 months
Hazard ratio
3.88
95% CI 1.93–7.80
P < 0.001
By group
IMH+vs MVO-/IMH-
HR 3.88 (95% CI 1.93–7.80); P < 0.001
As reported in the abstract
Further pooled results
- Infarct size · 3 days after PCI — IMH+
- 27%
- EF · 3 days after PCI — IMH+
- 45%
- Infarct size: MVO+/IMH- 19%
- Infarct size: MVO-/IMH- 18%
- Infarct size: P < 0.001
- EF: MVO+/IMH- 50%
- EF: MVO-/IMH- 54%
- EF: P < 0.001
MVI prevalence
- MVI occurred
- 633 (57%)
- MVO+/IMH- pattern
- 274 (25%)
- IMH+ pattern
- 359 (32%)
Original publication
Clinical Outcomes Associated With Various Microvascular Injury Patterns Identified by CMR After STEMI. J Am Coll Cardiol. Published 28 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →