Clinical Outcomes Based on Coronary Computed Tomography-Derived Fractional Flow Reserve and Plaque Characterization
Main finding · Cardiac events (per 100 vessel years)Result — go to the resultHazard ratio 16.67 95% CI 2.63–105.39Authors' conclusion
POC-FFRCT <0.80 and the presence of HRP were the independent predictors of cardiac events, and revascularization of HRP lesions with abnormal POC-FFRCT was associated with a lower event rate.
Study context
- Population
- Patients with chronic coronary syndrome undergoing coronary computed tomography angiography (CTA) as initial test, treated medically or with revascularization based on invasive coronary angiography, September 2015–December 2020of 5,483 undergoing CTA
- Participants
- 745 patients
- Exposure
- POC-FFRCT <0.80 vs ≥0.8 and high-risk plaque (HRP) vs no HRP
- Outcome
- Composite of:
- Cardiac death
- ACS
- Unplanned revascularization
- Follow-up
- Median 744 days
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
Cardiac events (per 100 vessel years)
Hazard ratio
16.67
95% CI 2.63–105.39
P = 0.002
By group
POC-FFRCT <0.80 and HRPvs POC-FFRCT ≥0.8 and no HRP
HR 16.67 (95% CI 2.63–105.39); P = 0.002
As reported in the abstract
- Cardiac events overall
- 20 patients (2.7%)
Observational data: associations, not effects.
Further findings
Adverse events in vessels with POC-FFRCT <0.80 and HRP, by revascularization
log-rank P = 0.006
Original publication
Clinical Outcomes Based on Coronary Computed Tomography-Derived Fractional Flow Reserve and Plaque Characterization. JACC Cardiovasc Imaging. Published 27 September 2023. doi:10.
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