Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial
Primary result · Mean total cardiac costsResult — go to the resultDifference +£114 (+8%) 95% CI -£112 (−8%) to +£337 (+23%)Authors' conclusion
A strategy of CTCA with selective FFRCT in patients with stable angina did not differ significantly from standard clinical care pathways in cost or clinical outcomes, but did reduce the use of invasive coronary angiography.
Study context
- Population
- Patients with stable chest pain
- Participants
- 1,400 patients
- Comparison
- Computed tomography coronary angiography (CTCA) with selective FFRCT vs standard care
- Primary endpoint
- Total cardiac costs
- Follow-up
- 9 months
Methodological detailsmulticentre (11 centres), Initial CTCA: 439 (63%) standard vs 674 (96%) experimental, 254 (38%) of whom underwent FFRCT
- Multicentre (11 centres)
- Initial CTCA: 439 (63%) standard vs 674 (96%) experimental, 254 (38%) of whom underwent FFRCT
Primary result
Mean total cardiac costs
Difference
+£114 (+8%)
95% CI -£112 (−8%) to +£337 (+23%)
P = 0.10
As reported in the abstract
Secondary outcomes
MACCE
Invasive coronary angiography · reduced significantly
P = 0.01
MACCE
- Did not differ significantly
Angina and quality of life · over follow-up
- Improved to a similar degree in both groups
Original publication
Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. Eur Heart J. Published 16 July 2021. doi:10.
Summarised from the published abstract; every number is checked against it