Arrhythmias & electrophysiologyCohort study
Clinical Outcomes by Sex After Pulsed Field Ablation of Atrial Fibrillation
- Retrospective cohort study
- multinational
- registry
- 24 European centres
Authors' conclusion
Results of this cohort study suggest that after PFA for AF, there were no significant sex differences in clinical effectiveness or safety events.
Study context
- Population
- Consecutive adults undergoing first-ever pulsed field ablation (PFA) for paroxysmal or persistent atrial fibrillation (AF), MANIFEST-PF registry, March 2021–May 2022
- Participants
- 1,568 adults
- Exposure
- Female vs male patients after PFA for AF
- Femalen = 553
- Malen = 1,015reference
- Outcome
- Freedom from clinically documented atrial arrhythmia ≥30 s after a 3-month blanking period; safety: composite of acute (<7 days) and chronic (>7 days) major adverse events
- Follow-up
- Median 1 year
Main finding
As reported in the abstract
Freedom from atrial arrhythmia (Kaplan-Meier estimate)
P = 0.28
Observational data: associations, not effects.
Further findings
PVI performed
Additional ablation performed
- PVI performed: P = .90
- Additional ablation performed: P = .79
Safety
Acute major AEs
- Acute major AEs: no significant difference, P = .19
Original publication
Clinical Outcomes by Sex After Pulsed Field Ablation of Atrial Fibrillation. JAMA Cardiol. Published 1 December 2023. doi:10.1001/jamacardio.2023.3752
Summarised from the published abstract; every number is checked against it