Arrhythmias & electrophysiology
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
Authors' conclusion
Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing post-approval pulsed field ablation (PFA) (mean age 64, 34.7% female, 57.8% paroxysmal AF, 35.2% persistent AF)106 of 116 centres
- Participants
- 17,642 patients
- Outcome
- Safety of PFA (complications)
Methodological detailspost-approval
- Post-approval
Main finding
As reported in the abstract
Major complications
Major complications
≈1%
173 of 17,642
Pericardial tamponade
0.36%; 63 of 17,642
Vascular events
0.30%; 53 of 17,642
Observational data: associations, not effects.
Original publication
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study. Nat Med. Published 8 July 2024. doi:10.
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