Arrhythmias & electrophysiology
Clinical Outcomes in Conduction System Pacing Compared to Right Ventricular Pacing in Bradycardia
Main findingResult — go to the resultAdjusted hazard ratio 0.53 95% CI 0.29–0.97Authors' conclusion
CSP significantly reduced adverse clinical outcomes for bradycardic patients requiring ventricular pacing
Study context
- Population
- Patients with pacemakers implanted for bradycardia, 2016–2021
- Participants
- 860 patients
- Exposure
- Conduction system pacing (CSP) vs right ventricular pacing (RVP)
- CSPn = 231
- RVPn = 628reference
- Outcome
- Composite of:
- HF hospitalization
- Upgrade to biventricular pacing or all-cause mortality
- Stratified by ventricular pacing burden (Vp)
Methodological details2 centres, consecutive patients
- 2 centres
- Consecutive patients
Main finding
As reported in the abstract
Adjusted hazard ratio
0.53
95% CI 0.29–0.97
P = 0.04
By group
CSPvs RVP
adjusted HR 0.53 (95% CI 0.29–0.97); P = 0.04
- Primary outcome, all patients
- 217 (25%)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| HF hospitalization (Vp >20%) | 0.40 (0.17–0.95) | P = 0.04 | |
| Primary outcome by pacing modality and VpCSP with Vp >20%vs RVP with Vp >20% | 0.51 (0.28–0.91) | P = 0.02 | |
| Primary outcome by pacing modality and VpAll patients with Vp ≤20%vs RVP with Vp >20% | 0.73 (0.54–0.99) | P = 0.04 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Primary outcome by pacing modality and Vp — CSP with Vp >20% vs RVP with Vp >20% · incidence 35% vs 10%
P < 0.001
- Primary outcome by pacing modality and Vp — Driven primarily by reductions in heart failure (HF) hospitalizations
- P < 0.05
Primary outcome by pacing modality and Vp
- Event-free survival similar between CSP with Vp >20% and those needing ≤20% Vp
Original publication
Clinical Outcomes in Conduction System Pacing Compared to Right Ventricular Pacing in Bradycardia. JACC Clin Electrophysiol. Published 30 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →