Arrhythmias & electrophysiology
Clinical Outcomes and Structural Remodelling After Ablation of Atrial Fibrillation in Heart Failure with Mildly Reduced or Mid-Range Ejection Fraction
Authors' conclusion
In patients with HFmrEF and AF, CA of AF could reduce both HF hospitalization and all-cause mortality as compared with those with MT. A significant improvement in LVEF and decrease in LA diameter were also observed in the CA group.
Study context
- Population
- Atrial fibrillation (AF) patients with echocardiography-proved HFmrEF and follow-up echocardiography, 2005–202036,879 screened
- Participants
- 72 vs 72
- Exposure
- Catheter ablation vs medical therapy
- Catheter ablation (CA)n = 72
- Medical therapy (MT)n = 72reference
- Outcome
- HF hospitalization and all-cause mortality
- Follow-up
- Mean 58.9 ± 42.6 months
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
mean follow-up 58.9 ± 42.6 months
CA vs MTHazard ratio (95% CI)P value
HF hospitalization
0.089(0.011–0.747)
P = 0.026All-cause mortality
0.121(0.016–0.894)
P = 0.038Observational data: associations, not effects.
Further findings
| Outcome | CA | MT | P value |
|---|---|---|---|
| Change in LVEF | +25.0% (SD 18.0%) | +6.2% (SD 21.6%) | P = <0.0001 |
| Change in LA diameter | −1.6 (SD 4.7) mm | +1.5 (SD 8.2) mm | P = 0.008 |
Original publication
Clinical Outcomes and Structural Remodelling After Ablation of Atrial Fibrillation in Heart Failure with Mildly Reduced or Mid-Range Ejection Fraction. ESC Heart Fail. Published 30 September 2022. doi:10.
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