Heart failure & cardiomyopathies
Clinical Phenotyping and Treatment Response in Patients With Chronic Heart Failure
Authors' conclusion
We identified 8 phenogroups with distinct clinical outcomes in patients with HF. This phenotyping provides appropriate risk stratification and may aid clinical decision-making in patients with HF.
Study context
- Population
- Chronic heart failure (HF) patients from the ELMSTAT-HF registry, enrolled between January 2020 and September 2024consecutive chronic HF patients examined, 2,317 patients enrolled in the registry
- Participants
- 2,301 patients
- Exposure
- Incidence of the primary outcome between the 8 phenogroups
- Outcome
- Composite of:
- All-cause death
- Hospitalization for worsening HF
- Follow-up
- Median 597 (IQR: 302-932) days
Methodological detailsregistry, latent class analysis using 99 clinical features, consecutive patients
- Registry
- Latent class analysis using 99 clinical features
- Consecutive patients
Main finding
As reported in the abstract
- Incidence of the primary outcome significantly differed between the phenogroups
- P < 0.001
Observational data: associations, not effects.
Further findings
Hospitalization for worsening HF in phenogroup 5, by beta-blocker or sodium-glucose cotransporter 2 inhibitor use
| HR (95% CI) | ||
|---|---|---|
| Patients taking beta-blockers | 2.20 (1.04–4.68) | |
| Patients taking sodium-glucose cotransporter 2 inhibitors | 4.27 (2.02–9.05) | |
| 0.10.31310Hazard ratio (log scale) |
- Hospitalization for worsening HF in phenogroup 5, by beta-blocker or sodium-glucose cotransporter 2 inhibitor use: significantly higher rate of hospitalization for worsening HF; comparator not stated
- Hospitalization for worsening HF in phenogroup 5, by beta-blocker or sodium-glucose cotransporter 2 inhibitor use: significantly higher rate of hospitalization for worsening HF; comparator not stated
Original publication
Clinical Phenotyping and Treatment Response in Patients With Chronic Heart Failure. JACC Adv. Published 17 July 2025. doi:10.
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