Arrhythmias & electrophysiology
Clinical Presentation and Long-Term Outcomes of Late-Onset Symptomatic Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Authors' conclusion
Clinical onset of ARVC after age 40 years is usually less severe than early-onset disease, despite similar structural phenotype, and is associated with slower VTs and less VT storm, and appears to have a lower risk of progression to clinical heart failure.
Study context
- Population
- Probands with definite ARVC (2010 Task Force criteria) and symptomatic arrhythmias at initial presentation, 2004–2024
- Participants
- 76 probands
- Exposure
- Late-onset vs early-onset symptomatic ARVC
- E-ARVCn = 50reference
- L-ARVCn = 26
- Outcome
- Presentation with cardiac arrest or syncope
Main finding
As reported in the abstract
P = 0.003
Observational data: associations, not effects.
Further findings
VT cycle length · mean follow-up
P < 0.001
Electrical storm · mean follow-up
P = 0.004
ICD therapies · mean follow-up
P < 0.001
- HF · mean follow-up 11.1 years · lower incidence in L-ARVC; printed 46.0% vs 19.2%
- P = 0.028
HF · mean follow-up 11.1 years
- Lower incidence of HF in L-ARVC
VT ablation success
- Similar success rates
Original publication
Clinical Presentation and Long-Term Outcomes of Late-Onset Symptomatic ARVC. JACC Clin Electrophysiol. Published 6 August 2025. doi:10.
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