Arrhythmias & electrophysiology
Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation: data from the RACE V study
Authors' conclusion
In self-terminating AF patients, the 4S-AF scheme does not predict AF progression. The 3S-AF scheme, excluding the symptom domain, may be a more appropriate score to predict AF progression.
Study context
- Population
- Patients with self-terminating atrial fibrillation (AF)
- Participants
- 341 patients
- Comparison
- 4S-AF scheme vs 3S-AF scheme for predicting AF progression
- Primary endpoint
- AF progression (to persistent or permanent AF, or self-terminating AF with >3% burden increase)
- Follow-up
- Median 2.1 (1.5-2.6) years
Methodological detailscontinuous monitoring with implantable loop recorders or pacemakers
- Continuous monitoring with implantable loop recorders or pacemakers
Primary result
As reported in the abstract
Prediction of AF progression
| Group | OR | C-statistic |
|---|---|---|
| 4S-AF | 1.1 (95% CI 0.88-1.41) | 0.53 |
| 3S-AF | 1.59 (95% CI 1.15-2.27) | 0.62 |
OR
4S-AF1.1 (95% CI 0.88-1.41)
3S-AF1.59 (95% CI 1.15-2.27)
C-statistic
4S-AF0.53
3S-AF0.62
Further findings
- Mean 4S-AF score
- 4.6 · average · SD 1.4
AF progression incidence
- Progression of AF
- 42 patients (12.3%, 5.9% per year)
Original publication
Clinical utility of the 4S-AF scheme in predicting progression of atrial fibrillation: data from the RACE V study. Europace. Published 1 March 2023. doi:10.
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