Arrhythmias & electrophysiology

Time of onset of atrial fibrillation and atrial fibrillation progression data from the RACE V study

EuropacePublished Secondary analysis of the RACE V prospective study

Authors' conclusion

In self-terminating AF, patients with either predominant nocturnal or daytime onset of AF episodes had less associated comorbidities and less AF progression compared to that of patients with mixed onset of AF.

Study context

Population
Patients with self-terminating atrial fibrillation (AF)
Participants
40 / 43 / 195
Comparison
Predominant nocturnal vs predominant daytime vs mixed AF onset
  • Nocturnaln = 40
  • Daytimen = 43
  • Mixedn = 195reference
Primary endpoint
AF progression
Follow-up
Median 2.2 (1.6-2.8) years
Methodological detailscontinuous rhythm monitoring with implantable loop recorder (ILR), Median age 66 (59-71) years; 117 (42%) women
  • Continuous rhythm monitoring with ILR
  • Median age 66 (59-71) years; 117 (42%) women

Primary result

As reported in the abstract

Nocturnal vs Mixed: P = 0.013 · Daytime vs Mixed: P = 0.008

Further findings

Obesity

OutcomeNocturnalDaytimeMixed
Number of comorbiditiesMedian223
Diabetes0%— not stated in the abstract12%

— not stated in the abstract

  • Number of comorbidities: P = 0.012
  • Diabetes: P = 0.031
  • Diabetes: group order as printed: mixed vs. daytime vs. nocturnal assumed ambiguous in abstract
  • Obesity: P = 0.028

Original publication

Time of onset of atrial fibrillation and atrial fibrillation progression data from the RACE V study. Europace. Published 27 March 2023. doi:10.1093/europace/euad058

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