Heart failure & cardiomyopathies
Clinical utility of QRS duration normalized to left ventricular volume for predicting cardiac resynchronization therapy efficacy in patients with “mid-range” QRS duration
Authors' conclusion
Modified QRSd can effectively predict the efficacy of CRT in patients with a "mid-range" QRSd.
Study context
- Population
- HF patients with "mid-range" QRS duration (QRSd) (120–149 ms) undergoing de novo cardiac resynchronization therapy (CRT) device implantationof 506 consecutive patients
- Participants
- 119 patients
- Exposure
- Modified QRSd (QRSd/left ventricular end-diastolic volume (LVEDV)) above vs below cutoff for predicting HF hospitalisation after CRT
- Outcome
- HF hospitalisation after CRT
- Follow-up
- Median 878 days [IQR 381-1663 days]
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
As reported in the abstract
HFH after CRT · median follow-up 878 days
Hazard ratio (95% CI)P value
Modified QRSdindependent predictor of HFH (Fine-Gray analysis)
0.97(0.96–0.99)
P < 0.01Above modified QRSd threshold (0.65 ms/mL)vs Below thresholdROC-derived cutoff
0.46(0.25–0.86)
P = 0.01- Heart failure hospitalization (HFH) occurred
- 45 patients (37%)
Observational data: associations, not effects.
Original publication
Clinical utility of QRS duration normalized to left ventricular volume for predicting cardiac resynchronization therapy efficacy in patients with “mid-range” QRS duration. Heart Rhythm. Published 15 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →