Arrhythmias & electrophysiologyCase-control study
Clonal haematopoiesis of indeterminate potential and atrial fibrillation: an east Asian cohort study
- Case-control study with cohort analysis
- deep-targeted sequencing
- UK Biobank outcome analysis
Authors' conclusion
CHIP mutations, primarily DNMT3A or TET2, are more prevalent in patients with AF than non-AF subjects whilst their presence is associated with a more progressive nature of AF and unfavourable clinical outcomes.
Study context
- Population
- Patients with atrial fibrillation (AF) and non-AF healthy subjects, east Asian cohort; UK Biobank AF subjects for outcomes
- Participants
- 1,004 vs 3,341
- Comparison
- AF vs non-AF subjects; Clonal haematopoiesis of indeterminate potential (CHIP) vs no CHIP within AF
- AFn = 1,004
- Non-AFn = 3,341reference
- Outcome
- Prevalence of CHIP mutations (variant allele fraction ≥ 2.0%) in AF vs non-AF subjects
Main finding
CHIP mutations (VAF ≥2.0%)
Adjusted odds ratio
1.38
95% CI 1.10–1.74
P < 0.01
Events by group
AF vs Non-AF
adjusted OR 1.38 (95% CI 1.10–1.74); P < 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values | adjusted OR (95% CI) | P value | |
|---|---|---|---|---|
| CHIP mutations by AF type — Long-standing persistent AF vs Non-AF | 1.50 (1.14–1.99) | P = 0.004 | ||
| TET2 somatic mutation | 1.65 (1.05–2.60) | P = 0.030 | ||
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | Values | adjusted OR | P value |
|---|---|---|---|
| CHIP mutations by AF type — Persistent AF vs Non-AF | 1.44 | ||
| CHIP mutations by AF type — Paroxysmal AF vs Non-AF | 1.33 | ||
| Composite of HF, ischaemic stroke or death in AF (UK Biobank) | CHIP n = 1297 · No CHIP n = 19 989 |
- Composite of HF, ischaemic stroke or death in AF (UK Biobank) — Risk with CHIP vs no CHIP
- 1.32-fold higher
- Composite of HF, ischaemic stroke or death in AF (UK Biobank): 21 286 AF subjects
Clinical characteristics of AF patients with vs without CHIP
- With CHIP: older, more DM, longer AF duration, higher E/E', more enlarged left atrium
- all P < .05
Original publication
Clonal haematopoiesis of indeterminate potential and atrial fibrillation: an east Asian cohort study. Eur Heart J. Published 17 January 2024. doi:10.1093/eurheartj/ehad869
Summarised from the published abstract; every number is checked against it