Heart failure & cardiomyopathies
Cardiac magnetic resonance (CMR) feature tracking–based left atrial mechanics predicts response to cardiac resynchronization therapy and adverse outcomes
Main finding · Detecting CRT responseResult — go to the resultχ2 40.83 vs 9.98Authors' conclusion
The preprocedure LA mechanics evaluated using CMR may be useful to predict response to CRT and improve risk stratification in CRT recipients.
Study context
- Population
- Cardiac resynchronization therapy (CRT) recipients with advanced heart failure (HF) and prolonged QRS duration, with preimplantation CMR
- Participants
- 163 recipients
- Exposure
- Left atrial (LA) mechanics by CMR feature tracking for predicting CRT response and outcomes
- CRT respondersn = 82
- Outcome
- (1) CRT response (LVEF improvement ≥5% plus reduction ≥1 NYHA class); (2) all-cause death or HF hospitalization
- Follow-up
- 6-month (response); median 41 months (outcomes)
Main finding
Detecting CRT response
χ2
40.83 vs 9.98
P < 0.001
Events by group
Responders
50.3%
82 of 82
As reported in the abstract
- CRT nonresponders had larger LA and worse LA reservoir and booster pump function than responders
- P < 0.001 for all
- Survival free from death or HF hospitalization increased with number of positive LA criteria
- log-rank, P < .001
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
CMR feature tracking–based left atrial mechanics predicts response to cardiac resynchronization therapy and adverse outcomes. Heart Rhythm. Published 16 March 2024. doi:10.
Summarised from the published abstract; every number is checked against it