Heart failure & cardiomyopathies
4D Digital Heart Model–Guided Left and Right Ventricular Lead Placement for Cardiac Resynchronization Therapy: Results of MAPIT-CRT Trial
Primary result · Increase in LVEF ≥5%Result — go to the resultRelative risk 1.80 95% CI 1.02–3.17Authors' conclusion
4DPcmr-guided LV/RV cardiac resynchronization therapy lead implantation using a practical web application was clinically feasible, safe, and was associated with greater LV ejection fraction improvement at 6 months versus standard of care with no increase in procedural times or complications.
Study context
- Population
- NYHA class II–IV HF on optimal medical therapy, LVEF ≤35%, QRS duration ≥120 msanalysed
- Participants
- 202 participants
- Comparison
- 4DPcmr-guided left ventricular (LV)/right ventricular (RV) lead placement vs standard lead placement for CRT
- 4DPcmr-guidedn = 105
- Controln = 96reference
- Primary endpoint
- Increase in LVEF ≥5%
- Follow-up
- 6 months
Methodological detailsmulticentre (7 Canadian sites)
- Multicentre (7 Canadian sites)
Primary result
As reported in the abstract
Relative risk
1.80
95% CI 1.02–3.17
P = 0.04
Events by treatment group
4DPcmr-guidedvs Control
RR 1.80 (95% CI 1.02–3.17); P = 0.04
Secondary outcomes
Absolute increase in LVEF
- Absolute LVEF increase, 4DPcmr-guided vs control
- 10.8% versus 5.8% (P=0.01)
All-cause mortality or HF hospitalization at 12 months, adverse outcomes, procedural times
- No differences between the 2 study arms
Safety
- No differences in rate of adverse outcomes between the 2 arms
Original publication
4D Digital Heart Model–Guided Left and Right Ventricular Lead Placement for Cardiac Resynchronization Therapy: Results of MAPIT-CRT Trial. Circ Arrhythm Electrophysiol. Published 25 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →