Heart failure & cardiomyopathies
Cardiac Magnetic Resonance (CMR) Findings in the Long-Term Outcomes After Multisystem Inflammatory Syndrome in Children (MUSIC) Study
Authors' conclusion
In this largest published multiinstitutional longitudinal CMR evaluation of confirmed patients with Multisystem Inflammatory Syndrome in Children, the prevalence of ventricular dysfunction and myocardial tissue characterization abnormalities on medium-term follow-up was low. However, a small number of patients had mild residual abnormalities at 6 months and 1 year following hospitalization.
Study context
- Population
- Patients with Multisystem Inflammatory Syndrome in Children undergoing cardiac magnetic resonance imaging after hospitalization263 CMRs analyzed
- Participants
- 255 patients
- Outcome
- Left ventricular dysfunction on first CMR
Methodological details32 centers in North America, CMR studies analyzed by a core laboratory
- 32 centers in North America
- CMR studies analyzed by a core laboratory
Main finding
As reported in the abstract
Left ventricular dysfunction present in first CMRs
17
6.7%
Observational data: associations, not effects.
Further findings
Dysfunction by timing of imaging
- At admission
- 4/7 (57%)
- At 3 months
- 5/87 (6.9%)
- At 6 months or 1 year post-hospitalization
- 6/129 (4.6%)
Late gadolinium enhancement
- Late gadolinium enhancement present
- 2 (0.8%)
- 1 at 3 months and another at 6 months following hospitalization
Coronary artery dilation
- Coronary artery dilation, of the 174 patients
- 13 of the 174 (7.5%)
Lake Louise criteria for myocarditis · at the time of CMR
- Patients meeting the Lake Louise criteria for myocarditis
- Nine (3.5%)
Patient age and timing of studies
- Mean patient age
- 11.4±4.4 years
- Studies performed at 3 months
- 33%
- Studies performed at 6 months
- 45%
Original publication
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