Heart failure & cardiomyopathies
Left atrial stiffness and strain are novel indices of left ventricular diastolic function in children: validation followed by application in multisystem inflammatory syndrome in children due to COVID-19
Authors' conclusion
In children with elevated PCWP, LA stiffness was significantly increased. When applied to children with MIS-C, LA stiffness classified myocardial injury accurately.
Study context
- Participants
- 43 / 33 / 28 / 14
- Comparison
- Elevated pulmonary capillary wedge pressure (PCWP) vs normal PCWP; Multisystem inflammatory syndrome in children (MIS-C) with vs without myocardial injury
- Elevated PCWPn = 43
- Normal PCWPn = 33reference
- Myocardial injury (+)n = 28
- Myocardial injury (-)n = 14reference
- Outcome
- LA stiffness (E/e' / LA peak strain) to differentiate elevated from normal PCWP
Methodological detailsvalidation cohort followed by application cohort
- Validation cohort followed by application cohort
Performance
As reported in the abstract
LA stiffness
P < 0.001
- ROC AUC for elevated PCWP
- 0.88
- Cutoff for elevated PCWP
- 0.27%-1
Further findings
Median
| Outcome | Elevated PCWP | Normal PCWP | P value |
|---|---|---|---|
| LA peak strainElevated PCWP vs Normal PCWP | 15.0% | 38.2% | P < 0.001 |
Left atrial (LA) stiffness for identifying myocardial injury in MIS-C
- AUC
- 0.79
- Cutoff
- 0.29%-1
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Left atrial stiffness and strain are novel indices of left ventricular diastolic function in children: validation followed by application in multisystem inflammatory syndrome in children due to COVID-19. Eur Heart J Cardiovasc Imaging. Published 9 May 2023. doi:10.
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