Cognitive impairment and outcomes in older adults with non-ST-elevation acute coronary syndrome
Authors' conclusion
Cognitive impairment in older patients with NSTEACS undergoing an invasive strategy was associated with long-term all-cause mortality.
Study context
- Population
- Patients aged ≥75 years with non-ST-elevation acute coronary syndrome (NSTEACS) undergoing an invasive strategycompleted long-term follow-up
- Participants
- 239 patients
- Exposure
- Cognitive impairment vs normal cognition
- Outcome
- MACE:
- All-cause death
- Reinfarction
- Stroke/TIA
- Urgent revascularisation
- Significant bleeding
- Follow-up
- 5-year follow-up
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
MACE
Cognition status not associated with MACE
HR 1.37
95% CI 0.96 to 1.95p=0.082
Observational data: associations, not effects.
Further findings
All-cause mortality · 5-year follow-up
- Significantly more deaths with cognitive impairment
- P = 0.005
- Kaplan-Meier survival analysis
- log-rank p=0.003
- Increased risk of all-cause mortality (Cox regression), adjusted for frailty and GRACE score
- aHR 1.85 (95% CI 1.11 to 3.08); p=0.018
Original publication
Cognitive impairment and outcomes in older adults with non-ST-elevation acute coronary syndrome. Heart. Published 9 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →